(−)-Epiafzelechin Protects against Ovariectomy-induced Bone Loss in Adult Mice and Modulate Osteoblastic and Osteoclastic Functions In Vitro
KC Wong, S Cao, X Dong, MC Law, TH Chan… - Nutrients, 2017 - mdpi.com
The present study was designed to characterize the bone protective effects of (−)-epi
afzelechin (EAF), a flavan-3-ol, in mature ovariectomized mice model and its ability to
stimulate osteoblastic activity and inhibit osteoclastic activity. Mature C57BL/6 mice (three to
four months old) were either ovariectomised (OVX) or sham-operated and subjected to
treatment (vehicle, 17β-oestradiol (E2, 200 μg/kg/day) or EAF (500 μg/kg/day) orally for six
weeks. EAF and E2 significantly reduced urinary calcium (Ca) excretion, serum osteocalcin …
afzelechin (EAF), a flavan-3-ol, in mature ovariectomized mice model and its ability to
stimulate osteoblastic activity and inhibit osteoclastic activity. Mature C57BL/6 mice (three to
four months old) were either ovariectomised (OVX) or sham-operated and subjected to
treatment (vehicle, 17β-oestradiol (E2, 200 μg/kg/day) or EAF (500 μg/kg/day) orally for six
weeks. EAF and E2 significantly reduced urinary calcium (Ca) excretion, serum osteocalcin …
(-)-Epiafzelechin protects against ovariectomy-induced bone loss in adult mice and modulate osteoblastic and osteoclastic functions in vitro.
WKC Wong KaChun, CSS Cao SiSi, DXL Dong XiaoLi… - 2017 - cabidigitallibrary.org
The present study was designed to characterize the bone protective effects of (-)-epi
afzelechin (EAF), a flavan-3-ol, in mature ovariectomized mice model and its ability to
stimulate osteoblastic activity and inhibit osteoclastic activity. Mature C57BL/6 mice (three to
four months old) were either ovariectomised (OVX) or sham-operated and subjected to
treatment (vehicle, 17β-oestradiol (E2, 200 µg/kg/day) or EAF (500 µg/kg/day)) orally for six
weeks. EAF and E2 significantly reduced urinary calcium (Ca) excretion, serum osteocalcin …
afzelechin (EAF), a flavan-3-ol, in mature ovariectomized mice model and its ability to
stimulate osteoblastic activity and inhibit osteoclastic activity. Mature C57BL/6 mice (three to
four months old) were either ovariectomised (OVX) or sham-operated and subjected to
treatment (vehicle, 17β-oestradiol (E2, 200 µg/kg/day) or EAF (500 µg/kg/day)) orally for six
weeks. EAF and E2 significantly reduced urinary calcium (Ca) excretion, serum osteocalcin …
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