(R)‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
ABSTRACT A diet supplemented with (R)‐lipoic acid, a mitochondrial coenzyme, was fed to
old rats to determine its efficacy in reversing the decline in metabolism seen with age. Young
(3 to 5 months) and old (24 to 26 months) rats were fed an AIN‐93M diet with or without (R)‐
lipoic acid (0.5% w/w) for 2 wk, killed, and their liver parenchymal cells were isolated.
Hepatocytes from untreated old rats vs. young controls had significantly lower oxygen
consumption (P< 0.03) and mitochondrial membrane potential.(R)‐Lipoic acid …
old rats to determine its efficacy in reversing the decline in metabolism seen with age. Young
(3 to 5 months) and old (24 to 26 months) rats were fed an AIN‐93M diet with or without (R)‐
lipoic acid (0.5% w/w) for 2 wk, killed, and their liver parenchymal cells were isolated.
Hepatocytes from untreated old rats vs. young controls had significantly lower oxygen
consumption (P< 0.03) and mitochondrial membrane potential.(R)‐Lipoic acid …
[引用][C] (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
H TM - FASEB J, 1999 - cir.nii.ac.jp
(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function,
decreased oxidative damage, and increased metabolic rate | CiNii Research … (R)-alpha-lipoic
acid-supplemented old rats have improved mitochondrial function, decreased oxidative
damage, and increased metabolic rate …
decreased oxidative damage, and increased metabolic rate | CiNii Research … (R)-alpha-lipoic
acid-supplemented old rats have improved mitochondrial function, decreased oxidative
damage, and increased metabolic rate …
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