[5] Access resistance and space clamp problems associated with whole-cell patch clamping
CM Armstrong, WF Gilly - Methods in enzymology, 1992 - Elsevier
Publisher Summary Without proper compensation for series resistance and demonstration of
a good space clamp, all measurements of membrane current are qualitative. This chapter
discusses the impediments that have harried investigators since the first development of the
voltage clamp. The illustrations provided in the chapter refer to several significant points:(1)
spatial uniformity of voltage under resting conditions does not imply spatial uniformity in the
active cell,(2) steady-state uniformity of voltage does not imply uniformity after a quick …
a good space clamp, all measurements of membrane current are qualitative. This chapter
discusses the impediments that have harried investigators since the first development of the
voltage clamp. The illustrations provided in the chapter refer to several significant points:(1)
spatial uniformity of voltage under resting conditions does not imply spatial uniformity in the
active cell,(2) steady-state uniformity of voltage does not imply uniformity after a quick …
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