[HTML][HTML] [68Ga] Ga-FAPI-46 synthesis on a GAIA® module system: Thorough study of the automated radiolabeling reaction conditions
L Rubira, C Donzé, J Fouillet, B Algudo… - Applied Radiation and …, 2024 - Elsevier
The influence of several parameters involved in the 68 Ga radiolabeling of FAPI-46 was
studied at the scale of the automated reaction. Among the buffers tested, HEPES 0.3 M pH 4
allowed both high radiochemical purity (RCP) and radiochemical yield (RCY), without
prepurification of 68 Ga but after final purification of [68 Ga] Ga-FAPI-46 on a C 18 cartridge.
A longer reaction time did not show significant benefit on the RCP, while higher loads of
FAPI-46 and gentisic acid as anti-radiolysis compound allowed better RCY.
studied at the scale of the automated reaction. Among the buffers tested, HEPES 0.3 M pH 4
allowed both high radiochemical purity (RCP) and radiochemical yield (RCY), without
prepurification of 68 Ga but after final purification of [68 Ga] Ga-FAPI-46 on a C 18 cartridge.
A longer reaction time did not show significant benefit on the RCP, while higher loads of
FAPI-46 and gentisic acid as anti-radiolysis compound allowed better RCY.
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