ΔNp63 Versatilely Regulates a Broad NF-κB Gene Program and Promotes Squamous Epithelial Proliferation, Migration, and Inflammation
X Yang, H Lu, B Yan, RA Romano, Y Bian, J Friedman… - Cancer research, 2011 - AACR
Head and neck squamous cell carcinoma (HNSCC) and many other epithelial malignancies
exhibit increased proliferation, invasion, and inflammation, concomitant with aberrant
nuclear activation of TP53 and NF-κB family members ΔNp63, cRel, and RelA. However, the
mechanisms of cross-talk by which these transcription factors coordinate gene expression
and the malignant phenotype remain elusive. In this study, we showed that ΔNp63 regulates
a cohort of genes involved in cell growth, survival, adhesion, and inflammation, which …
exhibit increased proliferation, invasion, and inflammation, concomitant with aberrant
nuclear activation of TP53 and NF-κB family members ΔNp63, cRel, and RelA. However, the
mechanisms of cross-talk by which these transcription factors coordinate gene expression
and the malignant phenotype remain elusive. In this study, we showed that ΔNp63 regulates
a cohort of genes involved in cell growth, survival, adhesion, and inflammation, which …
[引用][C] Correction: ΔNp63 Versatilely Regulates a Broad NF-κB Gene Program and Promotes Squamous Epithelial Proliferation, Migration, and Inflammation
X YANG, H LU, B YAN, R ROMANO… - Cancer …, 2011 - American Association for Cancer …
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