… with PD and/or modulating α-Syn aggregation is subject of active … aggregation pathways
and its modulation by cellular factors and selected environmental factors that may modulate …

… the presence of α-synuclein (αSyn) aggregates known as Lewy bodies. αSyn aggregation
is one of the leading causes for the neuronal dysfunction and death in PD. It is also associated …

… and (2) the deposition of misfolded α-synuclein (α-syn) as amyloid … its oxidative intermediates
in modulating the aggregation … Model of α-synuclein aggregation pathways. Amyloid fibril …

… Notably, Alzheimer’s disease is characterized by the aggregation of the amyloid-β peptide
(Aβ), while Parkinson’s disease (PD) is linked to α-synuclein (αS) aggregation. A growing …

… α-synuclein structural characteristics as well as its posttranscriptional modifications and
alternative splicing, all of them crucial aspects of the aggregation … may modulate α-synuclein …

… aggregation propensity of α-synuclein, including oxidative stress, posttranslational modifications
in α-synuclein, … Proposed strategies to stop or reduce α-synuclein aggregation include …

… in the α-synuclein aggregation pathway. Multitude NMR studies probed the residues involved
in the LPS-binding structural motif that modulates … , LPS modulates the overall aggregation …

… In order to better understand the molecular mechanisms of α-synuclein aggregation and to
… of α-synuclein is extremely sensitive to its environment and can be easily modulated by a …

… In the present work, we have investigated the conformational and aggregation properties
of human α-syn and its familial mutants A30P, A53T, E46K and H50Q in the presence of Ca(II) …

… Next, we explored whether NPs can modulate αSYN content within microglia. We treated
microglia with fluorescently labeled αSYN and performed immunocytochemical staining to …