β-Carboline alkaloids from Galianthe ramosa inhibit malate synthase from Paracoccidioides spp.
CS de Freitas, L Kato, CMA de Oliveira… - Planta …, 2014 - thieme-connect.com
Planta medica, 2014•thieme-connect.com
As part of our continuing chemical and biological analyses of Rubiaceae species from
Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin,
ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase
from the pathogenic fungus Paracoccidioides spp. This enzyme is considered an important
molecular target because it is not found in humans. Molecular docking simulations were
used to describe the interactions between the alkaloids and malate synthase.
Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin,
ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase
from the pathogenic fungus Paracoccidioides spp. This enzyme is considered an important
molecular target because it is not found in humans. Molecular docking simulations were
used to describe the interactions between the alkaloids and malate synthase.
As part of our continuing chemical and biological analyses of Rubiaceae species from Cerrado, we isolated novel alkaloids 1 and 2, along with known compounds epicatechin, ursolic acid, and oleanolic acid, from Galianthe ramosa. Alkaloid 2 inhibited malate synthase from the pathogenic fungus Paracoccidioides spp. This enzyme is considered an important molecular target because it is not found in humans. Molecular docking simulations were used to describe the interactions between the alkaloids and malate synthase.
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