β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass
RN Kulkarni, M Holzenberger, DQ Shih, U Ozcan… - Nature …, 2002 - nature.com
Regulation of glucose homeostasis by insulin depends on the maintenance of normal β-cell
mass and function. Insulin-like growth factor 1 (Igf1) has been implicated in islet
development and differentiated function 1, 2, but the factors controlling this process are
poorly understood. Pancreatic islets produce Igf1 and Igf2, which bind to specific receptors
on β-cells 3, 4, 5, 6. Igf1 has been shown to influence β-cell apoptosis 7, and both Igf1 and
Igf2 increase islet growth 8, 9; Igf2 does so in a manner additive with fibroblast growth factor …
mass and function. Insulin-like growth factor 1 (Igf1) has been implicated in islet
development and differentiated function 1, 2, but the factors controlling this process are
poorly understood. Pancreatic islets produce Igf1 and Igf2, which bind to specific receptors
on β-cells 3, 4, 5, 6. Igf1 has been shown to influence β-cell apoptosis 7, and both Igf1 and
Igf2 increase islet growth 8, 9; Igf2 does so in a manner additive with fibroblast growth factor …
[引用][C] β-cell specific deletion of the IGF-1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cel mass
K RN - Nat Genet, 2002 - cir.nii.ac.jp
β-cell specific deletion of the IGF-1 receptor leads to hyperinsulinemia and glucose intolerance
but does not alter β-cel mass | CiNii Research … β-cell specific deletion of the IGF-1
receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cel mass …
but does not alter β-cel mass | CiNii Research … β-cell specific deletion of the IGF-1
receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cel mass …
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