β-sitosterol reverses multidrug resistance via BCRP suppression by inhibiting the p53–MDM2 interaction in colorectal cancer
Z Wang, Y Zhan, J Xu, Y Wang, M Sun… - Journal of agricultural …, 2020 - ACS Publications
Phytosterols are widely present in vegetable oils, nuts, cereal products, fruits, and berries.
Phytosterol-induced treatment sensitivity has recently shed light on alleviating multidrug
resistance in cancer therapy. Here, we demonstrated that β-sitosterol, the most common
dietary phytosterol, recovers oxaliplatin (OXA) sensitivity in drug-resistant colorectal cancer
(CRC) cells by inhibiting breast cancer resistance protein (BCRP) expression. We further
showed evidence that β-sitosterol could activate p53 by disrupting the p53–MDM2 …
Phytosterol-induced treatment sensitivity has recently shed light on alleviating multidrug
resistance in cancer therapy. Here, we demonstrated that β-sitosterol, the most common
dietary phytosterol, recovers oxaliplatin (OXA) sensitivity in drug-resistant colorectal cancer
(CRC) cells by inhibiting breast cancer resistance protein (BCRP) expression. We further
showed evidence that β-sitosterol could activate p53 by disrupting the p53–MDM2 …
ß-sitosterol reverses multidrug resistance via BCRP suppression by inhibiting the p53-MDM2 interaction in colorectal cancer.
Z Wang, Y Zhan, J Xu, Y Wang, M Sun, J Chen, T Liang… - 2020 - cabidigitallibrary.org
Phytosterols are widely present in vegetable oils, nuts, cereal products, fruits, and berries.
Phytosterol-induced treatment sensitivity has recently shed light on alleviating multidrug
resistance in cancer therapy. Here, we demonstrated that β-sitosterol, the most common
dietary phytosterol, recovers oxaliplatin (OXA) sensitivity in drug-resistant colorectal cancer
(CRC) cells by inhibiting breast cancer resistance protein (BCRP) expression. We further
showed evidence that β-sitosterol could activate p53 by disrupting the p53-MDM2 …
Phytosterol-induced treatment sensitivity has recently shed light on alleviating multidrug
resistance in cancer therapy. Here, we demonstrated that β-sitosterol, the most common
dietary phytosterol, recovers oxaliplatin (OXA) sensitivity in drug-resistant colorectal cancer
(CRC) cells by inhibiting breast cancer resistance protein (BCRP) expression. We further
showed evidence that β-sitosterol could activate p53 by disrupting the p53-MDM2 …
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