β2-microglobulin gene duplication in cetartiodactyla remains intact only in pigs and possibly confers selective advantage to the species
Several β2-microglobulin (B2M)-bound protein complexes undertake key roles in various
immune system pathways, including the neonatal Fc receptor (FcRn), cluster of
differentiation 1 (CD1) protein, non-classical major histocompatibility complex (MHC), and
well-known MHC class I molecules. Therefore, the duplication of B2M may lead to an
increase in the biological competence of organisms to the environment. Based on the pig
genome assembly SSC10. 2, a segmental duplication of~ 45.5 kb, encoding the entire B2M …
immune system pathways, including the neonatal Fc receptor (FcRn), cluster of
differentiation 1 (CD1) protein, non-classical major histocompatibility complex (MHC), and
well-known MHC class I molecules. Therefore, the duplication of B2M may lead to an
increase in the biological competence of organisms to the environment. Based on the pig
genome assembly SSC10. 2, a segmental duplication of~ 45.5 kb, encoding the entire B2M …
β2-microglobulin gene duplication in cetartiodactyla remains intact only in pigs and possibly confers selective advantage to the species.
TML Thong Minh Le, QVCL Quy Van Chanh Le… - 2017 - cabidigitallibrary.org
Abstract Several β2-microglobulin (B2 M)-bound protein complexes undertake key roles in
various immune system pathways, including the neonatal Fc receptor (FcRn), cluster of
differentiation 1 (CD1) protein, non-classical major histocompatibility complex (MHC), and
well-known MHC class I molecules. Therefore, the duplication of B2 M may lead to an
increase in the biological competence of organisms to the environment. Based on the pig
genome assembly SSC10. 2, a segmental duplication of∼ 45.5 kb, encoding the entire B2 …
various immune system pathways, including the neonatal Fc receptor (FcRn), cluster of
differentiation 1 (CD1) protein, non-classical major histocompatibility complex (MHC), and
well-known MHC class I molecules. Therefore, the duplication of B2 M may lead to an
increase in the biological competence of organisms to the environment. Based on the pig
genome assembly SSC10. 2, a segmental duplication of∼ 45.5 kb, encoding the entire B2 …
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