… 2’-modified nucleosides which are candidates for use in oligonucleotide theraputics. … group
effects the binding affinity of the 2’-modified oligonucleotides to complementary RNA [18]. As …

… all of the 2’modified oligonucleotides hybridized with greater aff… of uniformly 2”modified
oligonucleotides revealed that these … in the action of antisense oligonucleotides and of RNase H …

… oligonucleotides exhibited very high thermal stability when hybridized with complementary
RNA. 2-O-(2-Methoxy)ethyl-2-thiothymidine modified oligonucleotide … oligonucleotide …

We have identified a small interfering RNA (siRNA) motif, consisting entirely of 2‘-O-methyl
and 2‘-fluoro nucleotides, that displays enhanced plasma stability and increased in vitro …

… This article focuses on the progress made in the design of 2’-modified antisense oligonucleotides
that act via an RNase H mechanism of action. The aim of this review is to summarize …

… 2‘-modified nucleosides designed specifically for incorporating labels into oligonucleotides.
… Large-scale synthesis of 11-mer oligonucleotides possessing the 2‘-modified nucleosides is …

… formed with short oligonucleotides, and long oligonucleotides have the tendency to bind
unspecifically. With oligonucleotides of appropriate length, oligonucleotide binding may depend …

… Both 2'-6>-methyl and 2'-Opropyl chimeric oligonucleotides have shown increased efficacy
… two oligoribonucleotide strands that are fully 2'-modified have higher TmS than both RNA:…

… For six sequences containing a few 2'-modified adenosines in … 2'-0-methyl ribonucleotides,
all 2'-modified adenosines with a … One objective of this research was to use oligonucleotides …

… oligonucleotide are critical. For example, chimeric RNase H1-dependent ASOs are designed
to consist of a central oligo deoxynucleotide region flanked by 2′ modified … of 2′ modified …