Oxysterols have essential effects on brain homeostasis and their levels are often altered in
neurodegenerative and neuroinflammatory diseases. Several studies have demonstrated
the cytotoxic effects of 25-HC on different cell lines, however, not much is known about its
effects on neurons in vivo. In this study, we examined the effects of 25-HC exposure on the
nervous system development in the zebrafish. We showed that survival rate of zebrafish
embryos/larvae is significantly decreased at doses of 25-HC above 40 μM. 25-HC was found …