Synthesis and antituberculosis activity of 5-methyl/trifluoromethoxy-1H-indole-2, 3-dione 3-thiosemicarbazone derivatives

Ö Güzel, N Karalı, A Salman - Bioorganic & medicinal chemistry, 2008 - Elsevier
… of substitution in the R 3 were efficient in … derivatives were more active than the corresponding
R 1 -fluoro substituted derivatives in the 1H-indole-2,3-dione 3-thiosemicarbazones. The …

Design and synthesis of novel 5, 6-disubstituted pyridine-2, 3-dione-3-thiosemicarbazone derivatives as potential anticancer agents

W Xie, S Xie, Y Zhou, X Tang, J Liu, W Yang… - European Journal of …, 2014 - Elsevier
thiosemicarbazide is a highly efficient pharmacophore in drug molecular design. Recently,
several kinds of thiosemicarbazone derivatives … some new pyridinone derivatives, wherein the …

[HTML][HTML] QSAR study of some 5-methyl/trifluoromethoxy-1H-indole-2, 3-dione-3-thiosemicarbazone derivatives as anti-tubercular agents

M Shahlaei, A Fassihi, A Nezami - Research in Pharmaceutical …, 2009 - ncbi.nlm.nih.gov
… Here we investigate the quantitative structure activity relationships of a series of 49 methyl/trifluoromethoxy
1H-indole-2,3-dione-3-thiosemicarbazone derivatives reported in literature …

Synthesis and structure–antituberculosis activity relationship of 1H-indole-2, 3-dione derivatives

N Karalı, A Gürsoy, F Kandemirli, N Shvets… - Bioorganic & medicinal …, 2007 - Elsevier
… -2,3-dione derivatives, we have synthesized 5-fluoro-1H-indole-2,3-dione-3-thiosemicarbazone
derivatives, in … These new 5-fluoro-1H-indole-2,3-dione derivatives along with previously …

Three novel compounds of 5-trifluoromethoxy-1H-indole-2, 3-dione 3-thiosemicarbazone: Synthesis, crystal structures and molecular interactions

FB Kaynak, S Özbey, N Karalı - Journal of Molecular Structure, 2013 - Elsevier
… in 3-substituted 2-indolinone derivatives revealed that 3-thiosemicarbazone formation of
the … Hall and co-workers reported a new class of isatin-3-thiosemicarbazones with selective …

Synthesis of 1H-Indole-2,3-Dione-3-Thiosemicarbazone Ribonucleosides as Antibacterial Agents

SE Kassab, GH Hegazy, NM Eid, KM Amin… - … and Nucleic Acids, 2010 - Taylor & Francis
… -2,3-dione-3-thiosemicarbazone ribonucleosides that carry … -indole-2,3-dione-3-thiosemicarbazone,
which is the basis of … -indole-2,3-dione-3-thiosemicarbazone derivatives possess …

Selective Cytotoxic Effects of 5-Trifluoromethoxy-1H-indole-2, 3-dione 3-Thiosemicarbazone Derivatives on Lymphoid-originated Cells

F Danışman-Kalındemirtaş… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
… -2,3dion 3-thiosemicarbazone derivatives have shown that … thiosemicarbazone structure
play a key role [15,16]. In 2016, cytotoxicities of various isatin 3-thiosemicarbazone derivatives

Synthesis and chemotherapeutic activities of 5-chloro-1H-indole-2, 3-dione 3-thiosemicarbazones

G Ermut, N Karalı, İ Çetin, M Topçul… - Marmara …, 2013 - dergipark.org.tr
thiosemicarbazone derivatives were recently tested. Pharmacophore analysis of active
compounds revealed that isatin-3-thiosemicarbazone … 2,3-dione 3-thiosemicarbazone derivatives

[HTML][HTML] Design, synthesis and antimycobacterial activity of thiazolidine-2, 4-dione-based thiosemicarbazone derivatives

N Trotsko, J Golus, P Kazimierczak, A Paneth… - Bioorganic …, 2020 - Elsevier
… The aims of the present research are synthesis of new thiosemicarbazone derivatives with
TZD core as well as the evaluation of their antimycobacterial potential and cytotoxicity in vitro. …

New 1H‐indole‐2,3dione 3thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors

P Eraslan‐Elma, A Akdemir, E Berrino… - Archiv der …, 2022 - Wiley Online Library
… Based on these data, in the present study, we synthesized 1H-indole-2,3-dione 3-thiosemicarbazone
derivatives to investigate the contribution of the sulfamoyl residue at the 3-position …