Digital imaging array technology and processing power are continuously developing and have reached a state where 4-dimensional (ie time-resolved 3C-3D) digital holographic PIV/PTV (4D-DHPIV/PTV) methods can be considered for macro fluid mechanics and turbulence investigations. This paper presents an in-line 4D-DHPIV/PTV methodology, which in addition to including the standard digital hologram reconstruction, incorporates advanced digital filtering to remove the virtual image effect, 3-dimensional volume deconvolution to reduce the depth-of-focus problem and the virtual image, an efficient one-pass 3-dimensional clustering algorithm coupled with a new predictive inverse reconstruction approach based on previous work in this area, to increase the particle reconstruction dynamic range and 3-dimensional reconstruction domain. In addition to the presentation of the details of this 4D-DHPIV/PTV method, additional performance results pertaining to bias particle position error and uncertainty of the particle position are presented as a function of particle concentration.