5‐hydroxytryptamine1A receptor density in the hippocampus of patients with temporal lobe epilepsy is associated with disease duration
NC Fonseca, HPG Joaquim, LL Talib… - European journal of …, 2017 - Wiley Online Library
European journal of neurology, 2017•Wiley Online Library
Background and purpose To date, no study has evaluated the association between
serotonin receptor density and clinical variables in patients with temporal lobe epilepsy
caused by hippocampal sclerosis (TLE‐HS) using hippocampal tissue. We evaluated 5‐
hydroxytryptamine1A receptor (5‐HT 1 AR) density in hippocampal tissue from patients with
TLE‐HS. Methods We analyzed the hippocampal tissue of 34 patients with
pharmacoresistant unilateral TLE‐HS. 5‐HT 1 AR density was measured using …
serotonin receptor density and clinical variables in patients with temporal lobe epilepsy
caused by hippocampal sclerosis (TLE‐HS) using hippocampal tissue. We evaluated 5‐
hydroxytryptamine1A receptor (5‐HT 1 AR) density in hippocampal tissue from patients with
TLE‐HS. Methods We analyzed the hippocampal tissue of 34 patients with
pharmacoresistant unilateral TLE‐HS. 5‐HT 1 AR density was measured using …
Background and purpose
To date, no study has evaluated the association between serotonin receptor density and clinical variables in patients with temporal lobe epilepsy caused by hippocampal sclerosis (TLE‐HS) using hippocampal tissue. We evaluated 5‐hydroxytryptamine1A receptor (5‐HT1AR) density in hippocampal tissue from patients with TLE‐HS.
Methods
We analyzed the hippocampal tissue of 34 patients with pharmacoresistant unilateral TLE‐HS. 5‐HT1AR density was measured using semiquantitative western blotting.
Results
There was an association between higher density of 5‐HT1AR and longer duration of epilepsy (Spearman correlation: P = 0.040; generalized linear model: P = 0.026).
Conclusions
This study demonstrated that hippocampal 5‐HT1AR density is associated with epilepsy duration in patients with TLE‐HS. The authors postulate that this may represent a potential regulatory enhancement of endogenous serotonergic neurotransmission in response to prolonged and enduring epileptiform activity in the hippocampal tissue of patients with pharmacoresistant TLE‐HS.
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