5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves
A Goyer, E Collakova, RD de la Garza… - Journal of Biological …, 2005 - ASBMB
5-Formyltetrahydrofolate (5-CHO-THF) is formed via a second catalytic activity of serine
hydroxymethyltransferase (SHMT) and strongly inhibits SHMT and other folate-dependent
enzymes in vitro. The only enzyme known to metabolize 5-CHO-THF is 5-CHO-THF
cycloligase (5-FCL), which catalyzes its conversion to 5, 10-methenyltetrahydrofolate.
Because 5-FCL is mitochondrial in plants and mitochondrial SHMT is central to
photorespiration, we examined the impact of an insertional mutation in the Arabidopsis 5 …
hydroxymethyltransferase (SHMT) and strongly inhibits SHMT and other folate-dependent
enzymes in vitro. The only enzyme known to metabolize 5-CHO-THF is 5-CHO-THF
cycloligase (5-FCL), which catalyzes its conversion to 5, 10-methenyltetrahydrofolate.
Because 5-FCL is mitochondrial in plants and mitochondrial SHMT is central to
photorespiration, we examined the impact of an insertional mutation in the Arabidopsis 5 …
以上显示的是最相近的搜索结果。 查看全部搜索结果