Environments shape people, and at the same time, people are attracted to environments that fit their characteristics because fit facilitates the achievement of people’s desired life outcomes, such as relationship satisfaction, work success, and well-being. In this article, we outline how persons and environments can fit, the relevance of fit and misfit for different life outcomes, and the benefits and pitfalls of different (mis)fit measures. We propose three directions for future research: (a) the use of both subjective and objective (mis)fit measures; (b) the consideration of complex dynamics between person and environment characteristics via pathways through multiple biological, experiential, behavioral, and social layers across the life span; and (c) the integration of insights from different disciplines, including psychology, sociology, neuroscience, and genetics, to move the field forward.