A TLR4-derived non-cytotoxic, self-assembling peptide functions as a vaccine adjuvant in mice
Vaccination is devised/formulated to stimulate specific and prolonged immune responses for
long-term protection against infection or disease. A vaccine component, namely adjuvant,
enhances antigen recognition by the host immune system and thereby stimulates its cellular
and adaptive responses. Especially synthetic Toll-like receptor (TLR) agonists having self-
assembling properties are considered as good candidates for adjuvant development. Here,
a human TLR4-derived 20-residue peptide (TR-433), present in the dimerization interface of …
long-term protection against infection or disease. A vaccine component, namely adjuvant,
enhances antigen recognition by the host immune system and thereby stimulates its cellular
and adaptive responses. Especially synthetic Toll-like receptor (TLR) agonists having self-
assembling properties are considered as good candidates for adjuvant development. Here,
a human TLR4-derived 20-residue peptide (TR-433), present in the dimerization interface of …
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