A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity
C Punyadeera, EM Schneider, D Schaffer… - … , trauma, and shock, 2010 - journals.lww.com
Materials and Methods: Our study group consisted of 16 patients, of which 6 died and 10
survived. We daily measured 28 plasma proteins, for the whole stay of the patients in the
ICU. Results: We observed that metalloproteinases and sE-selectin play a role in the
distinction between SIRS and sepsis, and that IL-1α, IP-10, sTNF-R2 and sFas appear to be
indicative for the progression from sepsis to septic shock. A combined measurement of MMP-
3,-10, IL-1α, IP-10, sIL-2R, sFas, sTNF-R1, sRAGE, GM-CSF, IL-1β and Eotaxin allows for a …
survived. We daily measured 28 plasma proteins, for the whole stay of the patients in the
ICU. Results: We observed that metalloproteinases and sE-selectin play a role in the
distinction between SIRS and sepsis, and that IL-1α, IP-10, sTNF-R2 and sFas appear to be
indicative for the progression from sepsis to septic shock. A combined measurement of MMP-
3,-10, IL-1α, IP-10, sIL-2R, sFas, sTNF-R1, sRAGE, GM-CSF, IL-1β and Eotaxin allows for a …
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