Amitriptyline is a widely prescribed tricyclic antidepressant (TCA) with a very concerning
cardiotoxicity profile, but it is one that has not been discussed much in literature. Here, we
present a case of amitriptyline toxicity presenting as myocarditis with pericardial
involvement. A 21-year-old male with no previous cardiac history presented to the
emergency department (ED) with a decreased level of consciousness after an amitriptyline
overdose as a suicidal attempt. For concerns with airway protection, the patient was …

Amitriptyline is a widely prescribed tricyclic antidepressant (TCA) with a very concerning
cardiotoxicity profile, but it is one that has not been discussed much in literature. Here, we
present a case of amitriptyline toxicity presenting as myocarditis with pericardial
involvement. A 21-year-old male with no previous cardiac history presented to the
emergency department (ED) with a decreased level of consciousness after an amitriptyline
overdose as a suicidal attempt. For concerns with airway protection, the patient was …