A chemoattractant-guided walk through lymphopoiesis: from hematopoietic stem cells to mature B lymphocytes
VY Lim, S Zehentmeier, C Fistonich, JP Pereira - Advances in immunology, 2017 - Elsevier
B lymphocytes develop from hematopoietic stem cells (HSCs) in specialized bone marrow
niches composed of rare mesenchymal lineage stem/progenitor cells (MSPCs) and
sinusoidal endothelial cells. These niches are defined by function and location: MSPCs are
mostly perisinusoidal cells that together with a small subset of sinusoidal endothelial cells
express stem cell factor, interleukin-7 (IL-7), IL-15, and the highest amounts of CXCL12 in
bone marrow. Though rare, MSPCs are morphologically heterogeneous, highly reticular …
niches composed of rare mesenchymal lineage stem/progenitor cells (MSPCs) and
sinusoidal endothelial cells. These niches are defined by function and location: MSPCs are
mostly perisinusoidal cells that together with a small subset of sinusoidal endothelial cells
express stem cell factor, interleukin-7 (IL-7), IL-15, and the highest amounts of CXCL12 in
bone marrow. Though rare, MSPCs are morphologically heterogeneous, highly reticular …
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