three-component photoredox reaction between alkene, thio (seleno) cyanate, and
bromomalonate is employed, generating a carbo-thio (seleno) cyanate intermediate that
undergoes a domino of reactions mediated by alumina column chromatography, leading to
valuable chalcogen pharmacophores. Mechanistic investigations using DFT and control
experiments reveals an intramolecular H-bond responsible for driving the domino forward.