A comparison between stem cells from the adult human brain and from brain tumors
M Varghese, H Olstorn, C Sandberg, EO Vik-Mo… - …, 2008 - journals.lww.com
OBJECTIVE To directly compare stem cells from the normal adult human brain (adult human
neural stem cells [AHNSC]), Grade II astrocytomas (AC II), and glioblastoma multiforme
(GBM), with respect to proliferative and tumor-forming capacity and differentiation potential.
METHODS Cells were isolated from tissue obtained during epilepsy surgery (AHNSCs) or
tumor surgery (glioma stem cells [GSC]). They were cultured and investigated in vitro or after
transplantation in immunodeficient mice. RESULTS Under identical experimental conditions …
neural stem cells [AHNSC]), Grade II astrocytomas (AC II), and glioblastoma multiforme
(GBM), with respect to proliferative and tumor-forming capacity and differentiation potential.
METHODS Cells were isolated from tissue obtained during epilepsy surgery (AHNSCs) or
tumor surgery (glioma stem cells [GSC]). They were cultured and investigated in vitro or after
transplantation in immunodeficient mice. RESULTS Under identical experimental conditions …
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