A competitive formation of DNA: RNA hybrid G-quadruplex is responsible to the mitochondrial transcription termination at the DNA replication priming site
Human mitochondrial DNA contains a distinctive guanine-rich motif denoted conserved
sequence block II (CSB II) that stops RNA transcription, producing prematurely terminated
transcripts to prime mitochondrial DNA replication. Recently, we reported a general
phenomenon that DNA: RNA hybrid G-quadruplexes (HQs) readily form during transcription
when the non-template DNA strand is guanine-rich and such HQs in turn regulate
transcription. In this work, we show that transcription of mitochondrial DNA leads to the …
sequence block II (CSB II) that stops RNA transcription, producing prematurely terminated
transcripts to prime mitochondrial DNA replication. Recently, we reported a general
phenomenon that DNA: RNA hybrid G-quadruplexes (HQs) readily form during transcription
when the non-template DNA strand is guanine-rich and such HQs in turn regulate
transcription. In this work, we show that transcription of mitochondrial DNA leads to the …
[PDF][PDF] A Competitive Formation of DNA: RNA Hybrid G-Quadruplex Is Responsible to the Mitochondrial Transcription Termination at the DNA Replication Priming Site
郑克威， 吴壬乙， 何意得， 肖姗， 张佳宇， 郝玉华， 谭铮 - 2014 - ir.ioz.ac.cn
Human mitochondrial DNA contains a distinctive guanine-rich motif denoted conserved
sequence block II (CSB II) that stops RNA transcription, producing prematurely terminated
transcripts to prime mitochondrial DNA replication. Recently, we reported a general
phenomenon that DNA: RNA hybrid G-quadruplexes (HQs) readily form during transcription
when the non-template DNA strand is guaninerich and such HQs in turn regulate
transcription. In this work, we show that transcription of mitochondrial DNA leads to the …
sequence block II (CSB II) that stops RNA transcription, producing prematurely terminated
transcripts to prime mitochondrial DNA replication. Recently, we reported a general
phenomenon that DNA: RNA hybrid G-quadruplexes (HQs) readily form during transcription
when the non-template DNA strand is guaninerich and such HQs in turn regulate
transcription. In this work, we show that transcription of mitochondrial DNA leads to the …
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