Healthcare has evolved significantly over time, from traditional healthcare systems to cutting-edge medical technologies. As these technologies advance, researchers have become interested in their usability. The usefulness of healthcare websites helps to provide more precise medical information. A comprehensive review of the literature is required to identify usability features, techniques, and issues in healthcare websites over a specified time period. In this study, articles from the years 2017–2021 are reviewed from well-known digital libraries i.e, IEEE, ACM, and ScienceDirect that include papers from various conferences, magazines, books, and journals. Initially, the study found 10,512 titles based on the search string developed from the proposed research questions which were then further filtered down to a total of 55 papers. This systematic literature review (SLR) summarises and collects relevant data in response to pre-defined research questions. This analysis of existing research will help website designers and developers, in developing more user-friendly healthcare websites for the users. In the future, this SLR will help in determining the optimal solutions and developing a framework for the identified usability challenges and limitations. It also includes employing the usability evaluation tools discovered by researchers to identify and fix usability issues on websites.