A computational prospect to aspirin side effects: Aspirin and COX-1 interaction analysis based on non-synonymous SNPs
Aspirin (ASA) is a commonly used nonsteroidal anti-inflammatory drug (NSAID), which
exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2),
while the inhibition of COX-1 by ASA leads to apparent side effects. In the present study, the
relationship between COX-1 non-synonymous single nucleotide polymorphisms (nsSNPs)
and aspirin related side effects was investigated. The functional impacts of 37 nsSNPs on
aspirin inhibition potency of COX-1 with COX-1/aspirin molecular docking were …
exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2),
while the inhibition of COX-1 by ASA leads to apparent side effects. In the present study, the
relationship between COX-1 non-synonymous single nucleotide polymorphisms (nsSNPs)
and aspirin related side effects was investigated. The functional impacts of 37 nsSNPs on
aspirin inhibition potency of COX-1 with COX-1/aspirin molecular docking were …
[PDF][PDF] A Computational Prospect to Aspirin Side Effects
MNMMT Hamzeh - Journal of medicinal chemistry, 2014 - academia.edu
Aspirin (ASA) is a commonly used nonsteroidal anti-inflammatory drug (NSAID), which
exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2),
while the inhibition of COX-1 by ASA leads to apparent side effects. In the present study, the
relationship between COX-1 non-synonymous single nucleotide polymorphisms (nsSNPs)
and Aspirin related side effects was investigated. The functional impacts of 37 nsSNPs on
aspirin inhibition potency of COX-1 with COX-1/aspirin molecular docking were …
exerts its therapeutic effects through inhibition of cyclooxygenase (COX) isoform 2 (COX-2),
while the inhibition of COX-1 by ASA leads to apparent side effects. In the present study, the
relationship between COX-1 non-synonymous single nucleotide polymorphisms (nsSNPs)
and Aspirin related side effects was investigated. The functional impacts of 37 nsSNPs on
aspirin inhibition potency of COX-1 with COX-1/aspirin molecular docking were …
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