A concise synthesis of (+)-deoxoprosophylline via Co (III)(salen)-catalyzed two stereocentered HKR of racemic azido epoxides
DA Devalankar, A Sudalai - Tetrahedron Letters, 2012 - Elsevier
An efficient synthesis of (+)-deoxoprosophylline has been achieved in high optical purity
(99% ee) from readily available cis-2-butene-1, 4-diol. The strategy employs Co-catalyzed
Hydrolytic Kinetic Resolution (HKR) of two stereocentered racemic azido epoxides and
diastereoselective intramolecular reductive cyclization as key reactions.
(99% ee) from readily available cis-2-butene-1, 4-diol. The strategy employs Co-catalyzed
Hydrolytic Kinetic Resolution (HKR) of two stereocentered racemic azido epoxides and
diastereoselective intramolecular reductive cyclization as key reactions.
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