A copula approach to joint modeling of longitudinal measurements and survival times using Monte Carlo expectation-maximization with application to AIDS studies

M Ganjali, T Baghfalaki - Journal of biopharmaceutical statistics, 2015 - Taylor & Francis
Journal of biopharmaceutical statistics, 2015Taylor & Francis
Joint modeling of longitudinal measurements and time to event data is often performed by
fitting a shared parameter model. Another method for joint modeling that may be used is a
marginal model. As a marginal model, we use a Gaussian model for joint modeling of
longitudinal measurements and time to event data. We consider a regression model for
longitudinal data modeling and a Weibull proportional hazard model for event time data
modeling. A Gaussian copula is used to consider the association between these two …
Joint modeling of longitudinal measurements and time to event data is often performed by fitting a shared parameter model. Another method for joint modeling that may be used is a marginal model. As a marginal model, we use a Gaussian model for joint modeling of longitudinal measurements and time to event data. We consider a regression model for longitudinal data modeling and a Weibull proportional hazard model for event time data modeling. A Gaussian copula is used to consider the association between these two models. A Monte Carlo expectation-maximization approach is used for parameter estimation. Some simulation studies are conducted in order to illustrate the proposed method. Also, the proposed method is used for analyzing a clinical trial dataset.
Taylor & Francis Online
以上显示的是最相近的搜索结果。 查看全部搜索结果