A delicate balance between antibody evasion and ACE2 affinity for Omicron BA. 2.75

J Huo, A Dijokaite-Guraliuc, C Liu, D Zhou, HM Ginn… - Cell reports, 2023 - cell.com
BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor
affinity… is increased 9-fold compared with BA.2; there is also evidence of escape of BA.2.75 from …

[PDF][PDF] A delicate balance between antibody evasion and ACE2 affinity for Omicron BA. 2.75

J Ren, DI Stuart, C Green - pure-oai.bham.ac.uk
BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor
affinity. … Here, we report the antigenic characterization of BA.2.75 compared with other Omicron

Mutations in the SARS-CoV-2 spike receptor binding domain and their delicate balance between ACE2 affinity and antibody evasion

S Xue, Y Han, F Wu, Q Wang - Protein & Cell, 2024 - academic.oup.com
… Interestingly, along with the antibody evasion, BA.1, BA.2, BA.4/5 and BA.2.75 showed …
Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS…

Balancing functional tradeoffs between protein stability and ACE2 binding in the SARS-CoV-2 omicron BA. 2, BA. 2.75 and XBB lineages: dynamics-based network …

G Verkhivker, M Alshahrani, G Gupta - Viruses, 2023 - mdpi.com
delicate balance between antibody evasion and ACE2 binding affinity was observed in
biophysical studies of the OmicronOmicron subvariants BA.1, BA.2, BA.3, BA.4/5, BA.2.12.1, and …

SARS-CoV-2 BA. 2.86 enters lung cells and evades neutralizing antibodies with high efficiency

L Zhang, A Kempf, I Nehlmeier, A Cossmann, A Richter… - Cell, 2024 - cell.com
… we show that BA.2.86, unlike other Omicron sublineages, enters … evasion of neutralizing
antibodies and optimization of ACE2 (… We found that BA.2.86 robustly binds ACE2, enters Calu-3 …

A structure-function analysis shows SARS-CoV-2 BA. 2.86 balances antibody escape and ACE2 affinity

C Liu, D Zhou, A Dijokaite-Guraliuc, P Supasa… - Cell Reports …, 2024 - cell.com
… -2 Omicron, contains … of BA.2.86 to evade the antibody response to infection using a panel
of vaccinated or naturally infected sera and find that it shows marginally less immune evasion

Distinct evolution of SARS-CoV-2 Omicron XBB and BA. 2.86/JN. 1 lineages combining increased fitness and antibody evasion

D Planas, I Staropoli, V Michel, F Lemoine… - Nature …, 2024 - nature.com
… of BA.5.2.3 and BA.2.75.3 lineages) or XBC (a recombinant of … compared BA.2.86.1 and JN.1
fusogenicity, affinity to ACE2, … that a delicate balance between ACE2 and TMPRSS2 levels …

Rapid escape of new SARS-CoV-2 Omicron variants from BA. 2-directed antibody responses

A Dijokaite-Guraliuc, R Das, D Zhou, HM Ginn, C Liu… - Cell Reports, 2023 - cell.com
… succession of Omicron sub-lineages with waves of BA.2 and then BA.4/5 … BA.2. We describe
a panel of 25 potent monoclonal antibodies (mAbs) generated from vaccinees suffering BA.…

SARS-CoV-2 Omicron Subvariants Do Not Differ Much in Binding Affinity to Human ACE2: A Molecular Dynamics Study

HL Nguyen, TQ Nguyen, MS Li - The Journal of Physical …, 2024 - ACS Publications
… improved receptor binding affinity and immune evasion. To shed … that among the Omicron
sublineages, BA.2.75 and BA.2.75.2 … of Omicron will result in the advancement of antibodies

… Ensembles, and Binding Energetics of the SARS-CoV-2 Omicron BA. 2.86 Spike Protein with ACE2 Host Receptor and Antibodies: Compensatory Functional Effects of …

N Raisinghani, M Alshahrani, G Gupta… - Journal of Chemical …, 2024 - ACS Publications
BA.5, and BA.2.75 variants revealed a common trend wherein the acquisition of specific
mutations that potentially promote immune evasion, possibly at the cost of reduced ACE2 affinity