A distinct microbiome signature in posttreatment Lyme disease patients

M Morrissette, N Pitt, A González, P Strandwitz… - MBio, 2020 - Am Soc Microbiol
… in their microbiome. We found that patients with PTLDS have a distinct microbiome signature,
… The signature is characterized by an increase in Blautia, a decrease in Bacteroides, and …

[PDF][PDF] A distinct microbiome signature in posttreatment Lyme disease patients. mBio 11: e02310-20

M Morrissette, N Pitt, A González, P Strandwitz… - 2020 - scienceopen.com
… in their microbiome. We found that patients with PTLDS have a distinct microbiome signature,
… The signature is characterized by an increase in Blautia, a decrease in Bacteroides, and …

Metabolic response in patients with post-treatment Lyme disease symptoms/syndrome

BL Fitzgerald, B Graham, MJ Delorey… - … Infectious Diseases, 2021 - academic.oup.com
… However, the ability to distinguish PTLDS patients from 2 separate cohorts provides strong
support that the use of objective metabolic signatures will be of value in the understanding of …

Borreliella burgdorferi antimicrobial-tolerant persistence in Lyme disease and posttreatment Lyme disease syndromes

FC Cabello, ME Embers, SA Newman, HP Godfrey - MBio, 2022 - Am Soc Microbiol
… cells from patients with treated Lyme disease and … patients with other bacterial diseases
and influenza. Both groups observed a distinct transcriptional signature in Lyme disease patients

Lyme disease and the pursuit of a clinical cure

H Adkison, ME Embers - Frontiers in Medicine, 2023 - frontiersin.org
post treatment Lyme disease syndrome (PTLDS) or just simply … other protein signatures
found in patients with chronic fatigue … The gut microbiome from PTLD patients was compared to …

Gene set predictor for post-treatment Lyme disease

DJB Clarke, AW Rebman, J Fan, MJ Soloski… - Cell Reports …, 2022 - cell.com
… 152 individuals with symptoms of post-treatment LD (PTLD) to … have an inflammatory
signature that is distinguished from the … , and a fecal microbiome signature have been associated …

Dysautonomia following Lyme disease: a key component of post-treatment Lyme disease syndrome?

BL Adler, T Chung, PC Rowe, J Aucott - Frontiers in Neurology, 2024 - frontiersin.org
… two separate case series, a total of seven patientsmicrobiome compared to controls with
and without a history of antibiotic exposure (111). Metabolites produced by the gut microbiome, …

[HTML][HTML] Lyme Disease and Post-treatment Lyme Disease Syndrome: current and developing treatment options

NC Talbot, NJ Spillers, P Luther, C Flanagan… - Cureus, 2023 - ncbi.nlm.nih.gov
… the genus Borrelia, Lyme disease can be caused by different strains depending on …
theorized to be a characteristic shift in the microbiome composition, which hygromycin A has been …

Current and emerging approaches for eliminating Borrelia burgdorferi and alleviating persistent Lyme disease symptoms

K Zafar, OC Azuama, N Parveen - Frontiers in Microbiology, 2024 - frontiersin.org
… of symptoms known as post-treatment Lyme disease syndrome (… is often a clear indication
of Lyme disease in the endemic … At clinically relevant doses, milder changes in gut microbiome

A selective antibiotic for Lyme disease

N Leimer, X Wu, Y Imai, M Morrissette, N Pitt… - Cell, 2021 - cell.com
Lyme disease are broad spectrum, damage the microbiome, … less disruptive to the fecal
microbiome than clinically relevant … Although the disease is largely similar between the different