A facile one-pot, three-component synthesis of a new series of thiazolyl pyrazoles: Anticancer evaluation, ADME and molecular docking studies
S Mamidala, RK Aravilli, K Vaarla… - Polycyclic Aromatic …, 2023 - Taylor & Francis
A series of thiazolyl pyrazoles (4a–f, 6a–f, and 8a–b) were synthesized by a conventional
method using thiosemicarbazide, substituted phenacyl bromides, or substituted 3-(2-
bromoacetyl) coumarins, 1-Boc-3-cyano-4-pyrrolidone, or 1-Boc-3-cyano-4-piperidone. All
synthesized compounds' structures were confirmed by spectral (1H-and 13C-NMR, FTIR,
Mass) and analytical data. The target compounds were screened for their in vitro anticancer
activity. The results found that the compound 8a and 8b has shown significant …
method using thiosemicarbazide, substituted phenacyl bromides, or substituted 3-(2-
bromoacetyl) coumarins, 1-Boc-3-cyano-4-pyrrolidone, or 1-Boc-3-cyano-4-piperidone. All
synthesized compounds' structures were confirmed by spectral (1H-and 13C-NMR, FTIR,
Mass) and analytical data. The target compounds were screened for their in vitro anticancer
activity. The results found that the compound 8a and 8b has shown significant …
A facile one-pot, three-component synthesis of a new series of thiazolyl pyrazole carbaldehydes: In vitro anticancer evaluation, in silico ADME/T, and molecular …
A series of thiazolyl pyrazole carbaldehydes (4a-n) were synthesized by conventional
method using thiosemicarbazide, substituted phenacyl bromides, substituted 3-
acetylcoumarins, and Vilsmeyer-Hack reagent. Structures of all the synthesized compounds
were confirmed by spectral (1 H & 13 C NMR, FTIR, Mass) and analytical data. The target
compounds were screened for their in vitro anticancer activity. From the results, it was found
that the compound 4m has shown significant antiproliferative activity against all tested cell …
method using thiosemicarbazide, substituted phenacyl bromides, substituted 3-
acetylcoumarins, and Vilsmeyer-Hack reagent. Structures of all the synthesized compounds
were confirmed by spectral (1 H & 13 C NMR, FTIR, Mass) and analytical data. The target
compounds were screened for their in vitro anticancer activity. From the results, it was found
that the compound 4m has shown significant antiproliferative activity against all tested cell …