With the resurgence of virtualization technologies and the development of multi-core technologies, the combination of the two becomes a trend. Therefore, inter-VM communication becomes a key part in how to improve the performance of virtual machines (VMs) basing on multi-core platform. In this paper, we first analyze the characteristics of multi-core tasks and the properties of virtual machine environment, and then classify processor cores into two categories basing on their different functions. According to the classification, we design an inter-VM communication mechanism with multi-core platform. It discards the traditional communication path between VMs which needs to via a trusted VM, sets up communication channels between virtual CPUs in different VMs and uses shared memory space to implement high-throughput communication of inter-VM. Experiment results have proved the efficiency of them.