A globin in the nucleus!

E Geuens, I Brouns, D Flamez, S Dewilde… - Journal of Biological …, 2003 - ASBMB
Cytoglobin and neuroglobin are recently discovered members of the globin family. In situ
hybridization localized neuroglobin mainly in brain and retina, while cytoglobin was expressed …

A globin for the brain

M Brunori, B Vallone - The FASEB Journal, 2006 - Wiley Online Library
The discovery that a myoglobin‐like hemeprotein (called neuroglobin) is expressed in our
brain raised considerable curiosity from the standpoints of biochemistry and pathophysiology …

Expression of α-and β-globin genes occurs within different nuclear domains in haemopoietic cells

KE Brown, S Amoils, JM Horn, VJ Buckle, DR Higgs… - Nature cell …, 2001 - nature.com
… locus, we carried out immuno-FISH experiments to assess the proximity of endogenous α-globin
alleles to heterochromatin in the nucleus of PHA-activated human T lymphocytes. As …

CpG islands as gene markers in the vertebrate nucleus

AP Bird - Trends in Genetics, 1987 - cell.com
… One case concerns the c~-globin pseudogene o~man TM. This nonfunctional globin gene
is closely related to the functional cz-globin gene, approximat, dy three out of every four …

Intron function in the nonsense-mediated decay of β-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm

J ZHANG, X SUN, Y QIAN, LE MAQUAT - Rna, 1998 - cambridge.org
… the abundance of nucleusassociated b-globin mRNA produced in HeLa cells from a human
b-globin gene driven by the human CMV immediate early promoter (Kugler et al+, 1995)+ …

Neuroglobin, a novel member of the globin family, is expressed in focal regions of the brain

PPA Mammen, JM Shelton… - … of Histochemistry & …, 2002 - journals.sagepub.com
… nuclei, median preoptic nucleus, and subbrachial nucleus. Moderate signals were detected
in the bed nucleus of the stria terminalis, the subfornical organ, thalamus, arcuate nucleus, …

The human β‐globin locus control region: A center of attraction

PP Levings, J Bungert - European journal of biochemistry, 2002 - Wiley Online Library
… Once the LCR holocomplex is generated, the globin locus is relocated to an area of the
nucleus enriched for macromolecular complexes involved in coactivation, chromatin remodeling (…

The identification of ferritin in the nucleus of K562 cells, and investigation of a possible role in the transcriptional regulation of adult β-globin gene expression

D Pountney, G Trugnan, M Bourgeois… - Journal of cell …, 1999 - journals.biologists.com
We studied the subcellular distribution of ferritin in K562 cells by immunofluorescence
techniques and have made a reappraisal of a direct binding interaction between ferritin and the …

A characterization of globin mRNA sequences in the nucleus of duck immature red blood cells

RK Strair, AI Skoultchi, DA Shafritz - Cell, 1977 - cell.com
… presumptive precursor to globin mRNA been chased into molecules the size of globin mRNA.
… the nucleus of duck immature red blood cells. We confirm the existence of nuclear globin

The 3′ Untranslated Region Complex Involved in Stabilization of Human α-globin mRNA Assembles in the Nucleus and Serves an Independent Role as a Splice …

X Ji, J Kong, RP Carstens… - Molecular and Cellular …, 2007 - Taylor & Francis
… αCPs bind hα-globin transcripts in the nucleus and then travel with the processed mRNA to
the cytoplasm. The possibility that association of αCPs with hα-globin transcripts may have a …