Recurrent vulvovaginal candidiasis (RVVC) is one of the most prevalent fungal infections in
humans, especially in developing countries; however, it is underestimated and regarded as
an easy-to-treat condition. RVVC may be caused by dysbiosis of the microbiome and other
host-, pathogen-, and antifungal drug-related factors. Although multiple studies on host-
related factors affecting the outcome have been conducted, such studies on Candida-
derived factors and their association with RVVC are lacking. Thus, fluconazole-tolerant …