A high-salt diet stimulates thick ascending limb eNOS expression by raising medullary osmolality and increasing release of endothelin-1
M Herrera, JL Garvin - American Journal of Physiology …, 2005 - journals.physiology.org
A high-salt diet increases renal endothelin (ET) production and thick ascending limb (THAL)
endothelial nitric oxide synthase (eNOS) expression. ET stimulates THAL eNOS expression
via ETB receptors. The tonicity of the renal medulla is highly variable, and hyperosmolality
stimulates ET-1 synthesis by endothelial cells. We hypothesized that a high-salt diet raises
medullary osmolality, increases ET release by the THAL, and thus enhances eNOS
expression. Seven days of high salt (1% NaCl in drinking water) increased eNOS …
endothelial nitric oxide synthase (eNOS) expression. ET stimulates THAL eNOS expression
via ETB receptors. The tonicity of the renal medulla is highly variable, and hyperosmolality
stimulates ET-1 synthesis by endothelial cells. We hypothesized that a high-salt diet raises
medullary osmolality, increases ET release by the THAL, and thus enhances eNOS
expression. Seven days of high salt (1% NaCl in drinking water) increased eNOS …
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