A highly active catalyst for Huisgen 1, 3-dipolar cycloadditions based on the tris (triazolyl) methanol− Cu (I) structure
S Özçubukçu, E Ozkal, C Jimeno… - Organic Letters, 2009 - ACS Publications
S Özçubukçu, E Ozkal, C Jimeno, MA Pericas
Organic Letters, 2009•ACS PublicationsA new tris (1-benzyl-1 H-1, 2, 3-triazol-4-yl) methanol ligand 3 has been prepared by a triple
Cu (I)-catalyzed alkyne− azide 1, 3-dipolar cycloaddition (CuAAC). Ligand 3 forms a stable
complex with CuCl, which catalyzes the Huisgen 1, 3-dipolar cycloaddition on water or
under neat conditions. Low catalyst loadings, short reaction times at room temperature, and
compatibility with free amino groups make 3· CuCl an outstanding catalyst for CuAAC.
Cu (I)-catalyzed alkyne− azide 1, 3-dipolar cycloaddition (CuAAC). Ligand 3 forms a stable
complex with CuCl, which catalyzes the Huisgen 1, 3-dipolar cycloaddition on water or
under neat conditions. Low catalyst loadings, short reaction times at room temperature, and
compatibility with free amino groups make 3· CuCl an outstanding catalyst for CuAAC.
A new tris(1-benzyl-1H-1,2,3-triazol-4-yl)methanol ligand 3 has been prepared by a triple Cu(I)-catalyzed alkyne−azide 1,3-dipolar cycloaddition (CuAAC). Ligand 3 forms a stable complex with CuCl, which catalyzes the Huisgen 1,3-dipolar cycloaddition on water or under neat conditions. Low catalyst loadings, short reaction times at room temperature, and compatibility with free amino groups make 3·CuCl an outstanding catalyst for CuAAC.
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