A host-independent role for Fasciola hepatica transforming growth factor-like molecule in parasite development
M Musah-Eroje, RC Hoyle, O Japa… - International Journal for …, 2021 - Elsevier
The trematode parasite Fasciola hepatica causes chronic infection in hosts, enabled by an
immunosuppressed environment. Both host and parasite factors are known to contribute to
this suggesting that avoidance of immunopathology is beneficial to both parties. We have
previously characterised a parasite transforming growth factor (TGF)-like molecule, FhTLM,
that interacts with host macrophages to prevent antibody-dependent cell cytotoxicity
(ADCC). FhTLM is one of many described helminth TGF homologues and multiple helminths …
immunosuppressed environment. Both host and parasite factors are known to contribute to
this suggesting that avoidance of immunopathology is beneficial to both parties. We have
previously characterised a parasite transforming growth factor (TGF)-like molecule, FhTLM,
that interacts with host macrophages to prevent antibody-dependent cell cytotoxicity
(ADCC). FhTLM is one of many described helminth TGF homologues and multiple helminths …