… the ACE2 binding site and because … human pandemic potential, can tolerate changes in
this domain with limited fitness cost. Therefore, we believe that other sites on the spike protein …

… the ACE2 binding site, and because … human pandemic potential, can tolerate changes in
this domain with limited fitness cost. Therefore, we believe that other sites on the spike protein …

… rather than the more conserved S2 subunit to confer immune escape from neutralizing Abs
(… anti-S2 neutralizing Ab revealed that both prefusion and postfusion spikes can be bound by …

… basis for their broad reactivity and revealed common antibody features targetable by broad
… focus on vaccines and antibodies targeting the most conserved regions of the spike protein.…

… The results revealed robust binding to spikes derived from all … -5 epitope is conserved across
the betacoronavirus genus, … -5 within these processes to confer protection in mice, though …

… 46/IGKV3-20 antibodies reveal a conserved mode of binding … signature, and bind in a
conserved manner to the spike protein. … five betacoronavirus subgenera to determine the degree …

… resonance (SPR) analysis revealed that 1249A8 prevents the … The Spike protein S2 domain
is more highly conserved … that robustly and reproducibly confer protection in humanities …

… at the S2′ site of the spike protein and … conserved in alpha- and beta-coronaviruses. MAbs
targeting the FP showed broad binding ability to alpha- and beta-coronavirus spike proteins. …

… the SARS-CoV-2 spike (S) protein, namely the N-terminal … study revealed that the epitope
bound by this antibody is … -targeting antibodies have been reported to confer protection in …

… In contrast, the relatively conserved S2 subunit of the S protein … Clinical studies revealed
that several RBD-specific antibody … antibodies promote exposure of the S2’cleavage site which …