Background Emotion regulation has been linked to specific brain networks based on
functional neuroimaging, but networks causally involved in emotion regulation remain
unknown. Methods We studied patients with focal brain damage (N= 167) who completed
the managing emotion subscale of the Mayer-Salovey-Caruso Emotional Intelligence Test, a
measure of emotion regulation. First, we tested whether patients with lesions to an a priori
network derived from functional neuroimaging showed impaired emotion regulation. Next …

Background Emotion regulation has been linked to specific brain networks based on
functional neuroimaging, but networks causally involved in emotion regulation remain
unknown. Methods In a brain lesion dataset (n= 167), we first tested the association between
lesions to an a priori network derived from functional neuroimaging and emotion regulation
ability. Next, we leveraged lesion network mapping to this lesion dataset to derive a de novo
brain network for emotion regulation. Finally, we used an independent lesion database (n …