Using a novel and versatile capillary microfluidic flow-focusing device we fabricated
monodisperse drug-loaded nanoparticles from biodegradable polymers. A model
amphiphilic drug (dexamethasone) was incorporated within the biodegradable matrix of the
particles. The influence of flow rate ratio, polymer concentration, and microreactor-focusing
channel dimensions on nanoparticles' size and drug loading has been investigated. The
microfluidic approach resulted in the production of colloidal polymeric nanoparticles with a …

Microreactors have been shown to be a powerful tool for the production of nanoparticles
(NPs); however, there is still a lack of understanding of the role that the microfluidic
environment plays in directing the nanoprecipitation process and the synthetized
nanoparticles size and morphology. We fabricated a novel capillary microfluidic device
using a newly designed modular apparatus by assembling commercial stainless steel
microcapillary tubes for HPLC through a cross junction. In this way, we realized a flow …