A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimer's disease
JH Morrison, DA Lewis, MJ Campbell, GW Huntley… - Brain research, 1987 - Elsevier
Brain research, 1987•Elsevier
Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles
in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein
labels a distinct subset of pyramidal cells in the normal human cortex which have a
distribution very similar to that of neurofibrillary tangles in brains from patients with
Alzheimer's disease. In addition, regions and layers that normally contain a high density of
such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few …
in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein
labels a distinct subset of pyramidal cells in the normal human cortex which have a
distribution very similar to that of neurofibrillary tangles in brains from patients with
Alzheimer's disease. In addition, regions and layers that normally contain a high density of
such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few …
Abstract
Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.
Elsevier
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