A new biginelli reaction procedure using potassium hydrogen sulfate as the promoter for an efficient synthesis of 3,4‐dihydropyrimidin‐2(1H)‐one
S Tu, F Fang, S Zhu, T Li, X Zhang… - Journal of heterocyclic …, 2004 - Wiley Online Library
S Tu, F Fang, S Zhu, T Li, X Zhang, Q Zhuang
Journal of heterocyclic chemistry, 2004•Wiley Online LibrarySimple and improved conditions have been found to carry out the Biginelli reaction for the
synthesis of 3, 4‐dihydropyrimidin‐2 (1H)‐one derivatives. This synthesis was performed
using potassium hydrogen sulfate as the promoter in ethylene glycol solution. Compared
with the classical Biginelli reaction conditions, this new method has the advantage of
excellent yields (85–95%) and short reaction time (0.5–2 h).
synthesis of 3, 4‐dihydropyrimidin‐2 (1H)‐one derivatives. This synthesis was performed
using potassium hydrogen sulfate as the promoter in ethylene glycol solution. Compared
with the classical Biginelli reaction conditions, this new method has the advantage of
excellent yields (85–95%) and short reaction time (0.5–2 h).
Abstract
Simple and improved conditions have been found to carry out the Biginelli reaction for the synthesis of 3,4‐dihydropyrimidin‐2(1H)‐one derivatives. This synthesis was performed using potassium hydrogen sulfate as the promoter in ethylene glycol solution. Compared with the classical Biginelli reaction conditions, this new method has the advantage of excellent yields (85–95%) and short reaction time (0.5–2 h).
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