A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β
TGF-β signaling promotes metastasis by controlling the expression of downstream target
genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-β-induced
lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates
colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer
metastasis.
genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-β-induced
lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates
colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer
metastasis.
TGF-β signaling promotes metastasis by controlling the expression of downstream target genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-β-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.
cell.com
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