In a recent review article titled “A new look at cerebrospinal fluid circulation”, Brinker et al.
comprehensively described novel insights from molecular and cellular biology as well as
neuroimaging research, which indicate that cerebrospinal fluid (CSF) physiology is much
more complex than previously believed. The glymphatic system is a recently defined brain-
wide paravascular pathway for CSF and interstitial fluid exchange that facilitates efficient
clearance of interstitial solutes, including amyloid-β, from the brain. Although further studies …