In recent years, industrial control systems have evolved toward stability and efficiency, increasing industrial control systems interconnected with the Internet, which means that industrial control systems are facing more serious cyber threats. Thus, it is critical for enterprises to consider issues related to data privacy and network security. Digital twin enables real-time synchronization and simulation of data from various physical components of industrial control systems. However, anomaly detection of twin data is still challenging because existing methods are usually multi-stage with tedious training and detection steps. Therefore, we propose a method called end-to-end anomaly detection with the aim to accomplish real-time anomaly detection quickly and accurately. In order to seek key features, multidimensional deconvolutional network and attention mechanism are applied to our model. The results of this study indicate that our method performs well on precision and F1 score in comparison to the state-of-art methods.