Cerebral blood flow (CBF) is uniquely regulated by the anatomical design of the cerebral
vasculature as well as through neurovascular coupling. The process of directing the CBF to
meet the energy demands of neuronal activity is referred to as neurovascular coupling.
Microvasculature in the brain constitutes the critical component of the neurovascular
coupling. Mitochondria provide the majority of ATP to meet the high-energy demand of the
brain. Impairment of mitochondrial function plays a central role in several age-related …