Fundamental processes that govern the lytic cycle of the intracellular parasite Toxoplasma
gondii are regulated by several signalling pathways. However, how these pathways are
connected remains largely unknown. Here, we compare the phospho-signalling networks
during Toxoplasma egress from its host cell by artificially raising cGMP or calcium levels. We
show that both egress inducers trigger indistinguishable signalling responses and provide
evidence for a positive feedback loop linking calcium and cyclic nucleotide signalling. Using …

Fundamental processes of obligate intracellular parasites, such as Toxoplasma gondii and
Plasmodium falciparum, are controlled by a set of plant-like calcium dependent kinases
(CDPKs), the conserved cAMP-and cGMP-dependent protein kinases (PKA and PKG),
secondary messengers and lipid signalling. While some major components of the signalling
networks have been identified, how these are connected remains largely unknown. Here,
we compare the phospho-signalling networks during Toxoplasma egress from its host cell …