[HTML][HTML] A preliminary study of bilateral color mapping of pig bladder vasculature demonstrates potential for acute hemi-ischemic events
ZE Cullingsworth, N Nandanan… - Translational …, 2021 - ncbi.nlm.nih.gov
ZE Cullingsworth, N Nandanan, NR Swavely, K Frolov, R Vince, R Zee, T Cisu, AP Klausner…
Translational Andrology and Urology, 2021•ncbi.nlm.nih.govBackground Chronic ischemia is a known risk factor for the development of lower urinary
tract symptoms (LUTS) and bladder hypocontractility. Less is known, however, about the
impact of acute ischemia. Classic teaching suggests that collateral circulation is robust in the
bladder and, therefore, loss of a single source of blood flow should have no deleterious
effect. This study aims to provide visual evidence that segmental vascular supply is critical
for maintaining adequate perfusion to the bladder. Methods Ex vivo pig bladders were …
tract symptoms (LUTS) and bladder hypocontractility. Less is known, however, about the
impact of acute ischemia. Classic teaching suggests that collateral circulation is robust in the
bladder and, therefore, loss of a single source of blood flow should have no deleterious
effect. This study aims to provide visual evidence that segmental vascular supply is critical
for maintaining adequate perfusion to the bladder. Methods Ex vivo pig bladders were …
Abstract
Background
Chronic ischemia is a known risk factor for the development of lower urinary tract symptoms (LUTS) and bladder hypocontractility. Less is known, however, about the impact of acute ischemia. Classic teaching suggests that collateral circulation is robust in the bladder and, therefore, loss of a single source of blood flow should have no deleterious effect. This study aims to provide visual evidence that segmental vascular supply is critical for maintaining adequate perfusion to the bladder.
Methods
Ex vivo pig bladders were cannulated bilaterally in the superior vesical arteries and perfused using contrasting red and green dye. Images were collected at each step of the perfusion dyeing process and these images were analyzed using a custom program to calculate the average hue of each side. Statistical analysis was performed using Student’s t-test.
Results
The two halves being perfused by separate arteries showed a statistically significant difference when compared (P< 0.05) on both the outer wall (n= 9) and in the mucosal layer (n= 4). On the outside wall, the average normalized hue of the green halves was 27.5±14.3, while the average normalized hue of the red halves was− 58.7±3.1. In the mucosa, the average normalized hue of the green halves was 34.5±17.4, while the average normalized hue of the red halves was− 51.5±3.5.
Conclusions
This study identified a novel color mapping method to study pig bladder vascular supply. The results demonstrated a lack of collateral blood flow, highlighting the possibly of acute hemi-ischemic event. However, further research in the effect of acute ischemia on bladder function is necessary.
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