A proline insertion-deletion in the spike glycoprotein fusion peptide of mouse hepatitis virus strongly alters neuropathology
Fusion peptides (FPs) in spike proteins are key players mediating early events in cell-to-cell
fusion, vital for intercellular viral spread. A proline residue located at the central FP region
has often been suggested to have a distinctive role in this fusion event. The spike
glycoprotein from strain RSA59 (PP) of mouse hepatitis virus (MHV) contains two central,
consecutive prolines in the FP. Here, we report that deletion of one of these proline residues,
resulting in RSA59 (P), significantly affected neural cell syncytia formation and viral titers …
fusion, vital for intercellular viral spread. A proline residue located at the central FP region
has often been suggested to have a distinctive role in this fusion event. The spike
glycoprotein from strain RSA59 (PP) of mouse hepatitis virus (MHV) contains two central,
consecutive prolines in the FP. Here, we report that deletion of one of these proline residues,
resulting in RSA59 (P), significantly affected neural cell syncytia formation and viral titers …
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