A quantitative trait locus for body fat on chromosome 1q43 in French Canadians: linkage and association studies
Obesity, 2006•Wiley Online Library
Objective: To explore a quantitative trait locus (QTL) on human chromosome 1q affecting
BMI, adiposity, and fat‐free mass phenotypes in the Quebec Family Study cohort. Research
Methods and Procedures: Non‐parametric sibpair and variance component linkage
analyses and family‐based association studies were performed with a dense set of
chromosome 1q43 microsatellites and single‐nucleotide polymorphism markers in 885 adult
individuals. Results: Linkage was observed between marker D1S184 and BMI (p= 0.0004) …
BMI, adiposity, and fat‐free mass phenotypes in the Quebec Family Study cohort. Research
Methods and Procedures: Non‐parametric sibpair and variance component linkage
analyses and family‐based association studies were performed with a dense set of
chromosome 1q43 microsatellites and single‐nucleotide polymorphism markers in 885 adult
individuals. Results: Linkage was observed between marker D1S184 and BMI (p= 0.0004) …
Abstract
Objective: To explore a quantitative trait locus (QTL) on human chromosome 1q affecting BMI, adiposity, and fat‐free mass phenotypes in the Quebec Family Study cohort.
Research Methods and Procedures: Non‐parametric sibpair and variance component linkage analyses and family‐based association studies were performed with a dense set of chromosome 1q43 microsatellites and single‐nucleotide polymorphism markers in 885 adult individuals.
Results: Linkage was observed between marker D1S184 and BMI (p = 0.0004) and with body fat mass or percentage body fat (p ≤ 0.0003), but no linkage was detected with fat‐free mass. Furthermore, significant linkages (p < 0.0001) were achieved with subsamples of sibpairs at both ends of phenotype distributions. Association studies with quantitative transmission disequilibrium tests refined the linkage to a region overlapping the regulator of G‐protein signaling 7 (RGS7) gene and extending to immediate upstream gene loci.
Discussion: The present study indicates that the QTL on chromosome 1q43 specifically affects total adiposity and provides a genetic mapping framework for the dissection of this adiposity locus.
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